Abstract #2856

Simulations of the BOLD Non-Linearity Based on a Viscoelastic Model for Capillary and Vein Compliance

Joerg Peter Pfannmoeller¹, Grant Addison Hartung¹, Xiaojun Cheng², Avery Berman¹, David Boas², and Jonathan Rizzo Polimeni¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Neurophotonics Center, Boston University, Boston, MA, United States

The stimulus duration depended nonlinearity of the BOLD response is difficult to model, as it often requires stimulus-specific parameter values. Here we have extended an existing framework of BOLD response modeling based on biophysical simulations of realistic microvascular anatomy and dynamics to incorporate viscoelastic properties of individual blood vessels and tissue. We then applied this model to examine BOLD response nonlinearities to long-duration stimuli. We find that this model largely captures the differences in BOLD responses observed to short- and long-duration stimuli.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.