Meeting Banner
Abstract #2856

Simulations of the BOLD Non-Linearity Based on a Viscoelastic Model for Capillary and Vein Compliance

Joerg Peter Pfannmoeller1, Grant Addison Hartung1, Xiaojun Cheng2, Avery Berman1, David Boas2, and Jonathan Rizzo Polimeni1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Neurophotonics Center, Boston University, Boston, MA, United States

The stimulus duration depended nonlinearity of the BOLD response is difficult to model, as it often requires stimulus-specific parameter values. Here we have extended an existing framework of BOLD response modeling based on biophysical simulations of realistic microvascular anatomy and dynamics to incorporate viscoelastic properties of individual blood vessels and tissue. We then applied this model to examine BOLD response nonlinearities to long-duration stimuli. We find that this model largely captures the differences in BOLD responses observed to short- and long-duration stimuli.

This abstract and the presentation materials are available to members only; a login is required.

Join Here