Neuroimaging studies in humans showed different patterns of BOLD responses in cerebellar vermis and cortical regions when performing tasks at different grip forces. In this study we investigated the basis of different cerebellar fMRI responses ex-vivo. Capillary dilation and neuronal activity were recorded in the vermis and hemisphere of mouse cerebellar slices, highlighting a region and frequency dependency of neurovascular responses in the granular layer. The correlation between neuronal activity and vessel diameter changes was explored through a computational model, which supported a central role played by the NMDAR-NO pathway in shaping the vasodilation time course.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords