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Abstract #2855

Neurovascular coupling in the cerebellum: reconstructing the neurophysiological basis of different cerebellar fMRI responses.

Anita Monteverdi1,2, Giuseppe Gagliano2, Stefano Casali2, Fulvia Palesi1,2, Claudia AM Gandini Wheeler-Kingshott 1,2,3, Lisa Mapelli2, and Egidio D'Angelo1,2
1Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy, 2Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 3Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom

Neuroimaging studies in humans showed different patterns of BOLD responses in cerebellar vermis and cortical regions when performing tasks at different grip forces. In this study we investigated the basis of different cerebellar fMRI responses ex-vivo. Capillary dilation and neuronal activity were recorded in the vermis and hemisphere of mouse cerebellar slices, highlighting a region and frequency dependency of neurovascular responses in the granular layer. The correlation between neuronal activity and vessel diameter changes was explored through a computational model, which supported a central role played by the NMDAR-NO pathway in shaping the vasodilation time course.

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