Meeting Banner
Abstract #2854

Packing hierarchical structures in myocardial tissue to synthesise a realistic substrate

Jan N Rose1, Andrew D Scott2,3, and Denis J Doorly1
1Department of Aeronautics, Imperial College London, London, United Kingdom, 2Cardiovascular Magnetic Resonance unit, Royal Brompton Hospital, London, United Kingdom, 3National Heart and Lung Institute, Imperial College London, London, United Kingdom

In order to facilitate parameter studies of diffusion tensor cardiovascular magnetic resonance through simulations, there is a need to synthesise realistic microstructural substrates. We developed an algorithm to pack arbitrary shapes (polygons) into an arbitrarily shaped target region. We pack cardiomyocytes into the myocardial cell groupings known as sheetlets. In turn, these sheetlets are packed into a voxel. Our method produces a substrate that is comparable to histology in both extra-cellular volume fraction and distribution of extra-cellular space. Future work aims to expand capabilities and extend packing from 2D to 3D.

This abstract and the presentation materials are available to members only; a login is required.

Join Here