In order to facilitate parameter studies of diffusion tensor cardiovascular magnetic resonance through simulations, there is a need to synthesise realistic microstructural substrates. We developed an algorithm to pack arbitrary shapes (polygons) into an arbitrarily shaped target region. We pack cardiomyocytes into the myocardial cell groupings known as sheetlets. In turn, these sheetlets are packed into a voxel. Our method produces a substrate that is comparable to histology in both extra-cellular volume fraction and distribution of extra-cellular space. Future work aims to expand capabilities and extend packing from 2D to 3D.
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