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Abstract #2853

Realistic diffusion tensor cardiovascular magnetic resonance simulations in a histology-based substrate: The effect of membrane permeability

Jan N Rose1, Ignasi Alemany1, Andrew D Scott2,3, and Denis J Doorly1
1Department of Aeronautics, Imperial College London, London, United Kingdom, 2Cardiovascular Magnetic Resonance unit, Royal Brompton Hospital, London, United Kingdom, 3National Heart and Lung Institute, Imperial College London, London, United Kingdom

Computational simulations and specifically random walks provide a unique opportunity to investigate how several confounding factors might affect the diffusion tensor cardiovascular magnetic resonance (DT-CMR) parameters. We investigate the effect of membrane permeability and diffusion time on the fractional anisotropy (FA) and mean diffusivity in a realistic histology-based 3D substrate considering two common sequence types. Comparing the results from permeable with that from impermeable membranes helps to considerably reduce FA towards levels expected from in-vivo DT-CMR. We further reveal that FA is unaffected by changes in diffusion times above 500ms. A similar, albeit weaker effect is observed regarding MD.

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