Meeting Banner
Abstract #2864

Impact of ASL modelling strategies on cerebral blood flow and reactivity assessment

Joana Pinto1, Nicholas P. Blockley2, James W. Harkin3, and Daniel P. Bulte1
1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, United Kingdom, 2School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, 3Respiratory Medicine Department, School of Medicine, University of Nottingham, Nottingham, United Kingdom

Despite most ASL cerebrovascular reactivity (CVR) studies being based on single-PLD approaches, it has been shown that the vascular spatiotemporal dynamics of cerebral blood flow (CBF) are altered during hypercapnia. This ultimately leads to inaccuracies in some ASL modelling assumptions, compromising CVR assessment. In this work, we test several multiple-PLD ASL modelling strategies and assess their impact on CBF dynamics and CVR assessment. In particular, the individual and combined impact of estimating dispersion effects and the macrovascular signal are evaluated in terms of quantification of several haemodynamic parameters using multiple-PLD ASL data during two different conditions (resting-state and hypercapnia).

This abstract and the presentation materials are available to members only; a login is required.

Join Here