The Virtual Brain (TVB) has been recently developed to simulate whole-brain dynamics in healthy and pathological conditions, including only cerebral nodes. However, it has been demonstrated that the integration of cerebro-cerebellar connections in TVB can improve its predictive power. Thus, in this study we integrated cerebro-cerebellar connectivity in TVB simulation exploring its impact on prediction of brain dynamics in three different conditions: healthy, Alzheimer’s disease and Frontotemporal Spectrum Disorder. Notably we demonstrated that cerebro-cerebellar circuits integration in the TVB further improve its predictive power, both in healthy and pathological states.
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