Abstract #2865

Improving the predictive power of The Virtual Brain in healthy and neurodegenerative diseases with cerebro-cerebellar loops integration.

Anita Monteverdi^1,2, Fulvia Palesi^1,2, Claudia AM Gandini Wheeler-Kingshott ^1,2,3, and Egidio D'Angelo^1,2

¹Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy, ²Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, ³NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom

The Virtual Brain (TVB) has been recently developed to simulate whole-brain dynamics in healthy and pathological conditions, including only cerebral nodes. However, it has been demonstrated that the integration of cerebro-cerebellar connections in TVB can improve its predictive power. Thus, in this study we integrated cerebro-cerebellar connectivity in TVB simulation exploring its impact on prediction of brain dynamics in three different conditions: healthy, Alzheimer’s disease and Frontotemporal Spectrum Disorder. Notably we demonstrated that cerebro-cerebellar circuits integration in the TVB further improve its predictive power, both in healthy and pathological states.

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