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Abstract #2865

Improving the predictive power of The Virtual Brain in healthy and neurodegenerative diseases with cerebro-cerebellar loops integration.

Anita Monteverdi1,2, Fulvia Palesi1,2, Claudia AM Gandini Wheeler-Kingshott 1,2,3, and Egidio D'Angelo1,2
1Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy, 2Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 3NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, United Kingdom

The Virtual Brain (TVB) has been recently developed to simulate whole-brain dynamics in healthy and pathological conditions, including only cerebral nodes. However, it has been demonstrated that the integration of cerebro-cerebellar connections in TVB can improve its predictive power. Thus, in this study we integrated cerebro-cerebellar connectivity in TVB simulation exploring its impact on prediction of brain dynamics in three different conditions: healthy, Alzheimer’s disease and Frontotemporal Spectrum Disorder. Notably we demonstrated that cerebro-cerebellar circuits integration in the TVB further improve its predictive power, both in healthy and pathological states.

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