Here we extend a recent approach employing biophysical simulations of realistic cortical microvascular anatomy and dynamics to test whether the topology of the microvasculature impact the BOLD response. We create 3D vascular anatomical networks with varying ratios of arteries to venules and simulated the effects on cerebral blood flow and volume responses. We observed a difference in the cerebral blood volume response after we varied the ratio of diving arteries to ascending veins.
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