Abstract #2920

Functional cerebral blood volume imaging of the mouse visual cortex using vascular space occupancy

Naman Jain¹, Atena Akbari¹, Markus Barth^1,2, and Kai-Hsiang Chuang^1,3

¹Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia, ²School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia, ³Queensland Brain Institute, The University of Queensland, Brisbane, Australia

Cerebral Blood Volume (CBV) – weighted vascular-space-occupancy (VASO) functional MRI (fMRI) has shown superior spatial specificity compared to the conventional gradient-echo blood-oxygen-level-dependent (BOLD) contrast in humans [1]. Although VASO fMRI has been used for CBV imaging in rats and monkeys, the applicability of this method in the mouse brain has not been investigated due to the technical challenges. In this study we examine the feasibility of VASO fMRI of the visual cortex in the anesthetized mouse.

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