This study aims to develop awake fMRI protocol to compare the resting state functional connectivity between awake state and anesthetized state (isoflurane or medetomidine + isoflurane) in the same mouse. The typical structure of resting state functional connectivity did not alter under ISO or MED+ISO anesthesia, but the connectivity strength and fractional amplitude of low frequency fluctuation in the cerebral cortex and the thalamic nuclei altered under anesthesia. These results indicate the availability of anesthesia on the resting state fMRI although the impact of anesthesia on neuronal activity should be considered.
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