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Abstract #2934

Awake fMRI shows an impact of anesthesia on resting state functional connectivity in mice

Tomokazu Tsurugizawa1
1Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

This study aims to develop awake fMRI protocol to compare the resting state functional connectivity between awake state and anesthetized state (isoflurane or medetomidine + isoflurane) in the same mouse. The typical structure of resting state functional connectivity did not alter under ISO or MED+ISO anesthesia, but the connectivity strength and fractional amplitude of low frequency fluctuation in the cerebral cortex and the thalamic nuclei altered under anesthesia. These results indicate the availability of anesthesia on the resting state fMRI although the impact of anesthesia on neuronal activity should be considered.

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