In this study, we have observed a dose-dependent difference the brain activity and functional connectivity of Rhesus monkeys during propofol-induced anesthesia. The overall change of ALFF values was insignificant, but under lighter level there was an increase in the prefrontal and occipital lobes and in the frontal lobe inversely. The FC values across hemispheres were highly synchronized under deep anesthesia, and gradually decreased under lighter. The pattern of change in functional connectivity values showed a significant decrease followed by a small increase, which may have some reference significance to reveal the brain network formation mechanisms during resting state.
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