Abstract #2936

Life-span development of brain functional connectivity in common marmosets

Rina Ito^1,2, Yuji Komaki², Fumiko Seki², Mayu Iida^1,2, Mitsuki Rikitake^1,2, Marin Nishio^1,2, Junichi Hata^1,3, and Takako Shirakawa¹

¹Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ²Live imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, ³Jikei University Graduate School of Medicine, Tokyo, Japan

Resting-state functional MRI enables to assess the psycho-neurological disease and developmental disability. The purpose of this study was finding the trend of functional connectivity life-span development in healthy common marmosets. We verified that the number of resting-state networks and its strength increased dramatically with age until common marmosets became adults (the age of 24 months) and declined steadily at older age after 24 months. The results demonstrated mostly the same data as human; therefore, it could apply as control models comparing with psycho-neurological disorder models in further research.

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