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Abstract #2936

Life-span development of brain functional connectivity in common marmosets

Rina Ito1,2, Yuji Komaki2, Fumiko Seki2, Mayu Iida1,2, Mitsuki Rikitake1,2, Marin Nishio1,2, Junichi Hata1,3, and Takako Shirakawa1
1Department of Radiological Sciences, Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, 2Live imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, 3Jikei University Graduate School of Medicine, Tokyo, Japan

Resting-state functional MRI enables to assess the psycho-neurological disease and developmental disability. The purpose of this study was finding the trend of functional connectivity life-span development in healthy common marmosets. We verified that the number of resting-state networks and its strength increased dramatically with age until common marmosets became adults (the age of 24 months) and declined steadily at older age after 24 months. The results demonstrated mostly the same data as human; therefore, it could apply as control models comparing with psycho-neurological disorder models in further research.

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