Abstract #2937

Suppression of the default mode network in mouse affects memory consolidation

Zengmin Li¹, Dilsher Athwal¹, and Kai-Hsiang Chuang^1,2

¹Queensland Brain Institute, The University of Queensland, St Lucia, Australia, ²Centre for Advance Imaging, The University of Queensland, Brisbane, Australia

1. To understand the role of default mode network in memory consolidation, we target the retrosplenial cortex, area 30 (A30) by inhibition after mice learned a spatial memory task.
2. Using DREADDs to inhibit A30 during fMRI, significant decrease of functional connectivity from this area was detected.
3. Behavior–connectivity correlation analysis reveals connectivity reduction is correlated with behavior performance in the probe test.
4. Our results support a potential role of A30 in memory consolidation

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