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Abstract #2937

Suppression of the default mode network in mouse affects memory consolidation

Zengmin Li1, Dilsher Athwal1, and Kai-Hsiang Chuang1,2
1Queensland Brain Institute, The University of Queensland, St Lucia, Australia, 2Centre for Advance Imaging, The University of Queensland, Brisbane, Australia

  • 1. To understand the role of default mode network in memory consolidation, we target the retrosplenial cortex, area 30 (A30) by inhibition after mice learned a spatial memory task.
  • 2. Using DREADDs to inhibit A30 during fMRI, significant decrease of functional connectivity from this area was detected.
  • 3. Behavior–connectivity correlation analysis reveals connectivity reduction is correlated with behavior performance in the probe test.
  • 4. Our results support a potential role of A30 in memory consolidation

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