Magnetic Resonance Imaging (MRI) biomarkers hold great potential to become key in understanding Huntington’s Disease (HD) pathophysiology as well as disease progression. We investigated longitudinal changes in spatiotemporal properties of transient brain-wide co-activation patterns (CAPs) during the brain’s resting-state (RS) in a mouse model of HD. We found early differences in the temporal components of two biologically prominent CAPs in the diseased mice and showed, using supervised learning, that spatial features of CAPs accurately distinguish the diseased animals from healthy. Our findings show the promise of RS-CAPs in the development of MRI-based biomarkers of HD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords