Magnetic Resonance Imaging (MRI) biomarkers hold great potential to become key in understanding Huntington’s Disease (HD) pathophysiology as well as disease progression. We investigated longitudinal changes in spatiotemporal properties of transient brain-wide co-activation patterns (CAPs) during the brain’s resting-state (RS) in a mouse model of HD. We found early differences in the temporal components of two biologically prominent CAPs in the diseased mice and showed, using supervised learning, that spatial features of CAPs accurately distinguish the diseased animals from healthy. Our findings show the promise of RS-CAPs in the development of MRI-based biomarkers of HD.
This abstract and the presentation materials are available to members only; a login is required.