The vestibular system is critical for bodily functions, yet it remains an underappreciated sense. Recently, seminal studies of the prolonged exposure to microgravity in space showed significant alteration in vestibular activity and circadian rhythms. However, little is known regarding the role of the central vestibular system in regulating the circadian clock. Here, we deploy fMRI and optogenetic stimulation of vestibular excitatory neurons to visualize the neural targets of the vestibular system in circadian circuits. We reveal that the central vestibular system provides inputs to the suprachiasmatic nucleus, optic nerve and locus coeruleus, notable regions that drive and regulate circadian rhythms.
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