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Abstract #2944

Direct Mapping of the Nucleus Accumbens Core and Shell using Deep Brain Stimulation with functional Magnetic Resonance Imaging in rats

Hyeon-Joong Kim1, Ryan S Clement2, Roger B Bagwell2, Tirko N Natasha2, Yen-Yu Ian Shih1, and Sung-Ho Lee1
1Center for Animal MRI, Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, United States, 2Actuated medical, Bellefonte, PA, United States

Nucleus accumbens (NAc) is known as the backbone of the reward circuit, which the core and shell appear to be dominant. To directly map their distinct functional connectivity structure, we employed simultaneous Deep Brain Stimulation (DBS) at NAc during functional Magnetic Resonance Imaging (fMRI) and demonstrated the difference of the functional organization between core and shell. MR compatible 16ch microprobe was utilized to stimulate multiple regions during single scan session. We expect this technique could be useful to dissect the therapeutic circuit of DBS in NAc in the preclinical approach.

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