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Abstract #2948

T1Ρ relaxation times for voxel-wise characterization of longitudinal changes in hip cartilage biochemistry

Koren Roach1, Richard Souza1, Sharmila Majumdar1, and Valentina Pedoia1
1UCSF, San Francisco, CA, United States

Hip osteoarthritis coincides with or is preceded by biochemical changes in articular cartilage,1, 2 which can be measured on a voxel-wise basis with magnetic resonance T and T2 relaxation times. In this study, we employed principal component analysis to characterize variation in longitudinal changes of hip cartilage T relaxation times across healthy subjects and those with early-to-moderate hip osteoarthritis. Our results indicated that over two years, a majority of the variation in T relaxation time changes was located in the deep layers of the acetabular cartilage.

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