Detecting early articular cartilage damage can help formulate preventive treatment plans for hemophilia arthropathy (HA). Magnetic responance imaging (MRI) T2 mapping has been used extensively to investigate early chondral changes in osteoarthritis; however, it has seldomly been applied to investigate HA. This study acquired T2-mapping results on 30 patients (54 knees) with HA and 15 volunteers (24 knees). Patients with HA had significantly higher knee cartilage T2 values than the healthy controls. The T2 values also increased with the disease severity, suggesting that MRI T2 mapping is a promising method for detecting early stage cartilage damage in patients with hemophilia.
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