Abstract #2950

Optimization of Relaxation along Fictitious Field (RAFF) Contrast to Detect Osteoarthritis

Seyed Amir Mirmojarabian¹, Victor Casula¹, Olli-Pekka Aro¹, Henning Henschel², Miika T Nieminen^1,3,4, and Timo Liimatainen^1,3

¹Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, ²Department of Medicinal Chemistry, Uppsala University, uppsala, Sweden, ³Medical Research Center, Oulu University Hospital, Oulu, Finland, ⁴Department of Diagnostic Radiology,, Oulu University Hospital, Oulu, Finland

Relaxation along Fictitious Field (RAFF) at various pulse durations was exploited to study the contrast in collagen phantoms and cartilage-mimicking phantoms. RAFF Relaxation times from collagen phantoms agreed with Bloch McConnell simulations. The maximum contrast between collagen phantoms with concentration difference was maximized when pulse duration was ~2.8 ms. Given the optimized pulse duration, our simulation results combined with ex vivo measurements suggest that hydroxyl groups concentration through proton exchange between collagen and free water may have significant role in T_RAFF contrast between intact and degraded cartilage.

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