Abstract #2958

Disruption of collagen fiber architecture after DMM surgery using high-resolution DTI

Nian Wang¹, Anthony J. Mirando², Yi Qi³, Matthew J. Hilton², and Charles E. Spritzer³

¹Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, United States, ²Department of Orthopaedic Surgery, Duke University, Durham, NC, United States, ³Department of Radiology, Duke University, Durham, NC, United States

Nondestructively probing the 3D collagen fiber architecture of articular cartilage is still challenging for both clinical and preclinical studies. Diffusion tensor imaging (DTI) is able to resolve the collagen fiber directions by quantifying the unique water diffusion properties in soft tissues. Applying DTI and tractography in cartilage is limited but may provide noninvasive imaging biomarkers for Osteoarthritis (OA). In this study we imaged rat knees after 8 weeks destabilization of the medial meniscus (DMM) surgery using a modified 3D diffusion-weighted spin-echo pulse sequence at both high spatial resolution and high angular resolution.

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