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Abstract #2957

Evaluation of Lesion Tissue Composition in Patients with Juvenile Osteochondritis Dissecans (JOCD) of the Knee Using T2* Mapping at 3T

Stefan Zbyn1,2, Cassiano Santiago1, Casey P. Johnson1,3, Kai D. Ludwig1,2, Lin Zhang4, Shelly Marette2, Marc A. Tompkins5, Bradley J. Nelson5, Takashi Takahashi2, Gregory J. Metzger1, Cathy S. Carlson3, and Jutta M. Ellermann1,2
1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 3Department of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States, 4Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States, 5Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, United States

Clinical MRI of patients with juvenile osteochondritis dissecans (JOCD) relies on morphological, spin echo imaging with long echo times that cannot unambiguously distinguish between the cartilaginous, fibrous and osseous tissues within lesions. This 3T study evaluates 34 JOCD lesions from 25 patients using morphological MRI and T2* mapping. JOCD progression was associated with a significant T2* decrease in progeny and interface. Additionally, significantly lower T2* in stage IV progeny and parent bone of stable lesions suggests increased bone density compared to the healthy, control bone. T2* mapping provides quantitative evidence of disease progression which may help inform clinical JOCD management.

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