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Abstract #2971

GagCEST Imaging of Healthy and OA Patients at 7 Tesla

Blake Alexander Benyard1, Ryan Armbruster1, Abigail Cember1, Neil Wilson2, Ravinder Reddy1, and Joshua Baker3
1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Siemens Medical Solutions USA Inc, Malvern, PA, United States, 3Penn Medicine, Rheumatology, Philadelphia Veterans’ Affairs Medical Center, Philadelphia, PA, United States

Imaging of knee cartilage is of enormous significance, particularly for patients with osteoarthritis (OA). In this work, we applied Glycosaminoglycans-weighted Chemical Exchange Saturation Transfer (GagCEST) magnetic resonance imaging (MRI) at 7 Telsa (7T) to OA and healthy patients. GagCEST MRI revealed an increase in GagCEST (%) values for control patients in comparison to OA patients and can serve as a sensitive molecular biomarker for quantifying early metabolic changes in cartilage.

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