Abstract #2971

GagCEST Imaging of Healthy and OA Patients at 7 Tesla

Blake Alexander Benyard¹, Ryan Armbruster¹, Abigail Cember¹, Neil Wilson², Ravinder Reddy¹, and Joshua Baker³

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Siemens Medical Solutions USA Inc, Malvern, PA, United States, ³Penn Medicine, Rheumatology, Philadelphia Veterans’ Affairs Medical Center, Philadelphia, PA, United States

Imaging of knee cartilage is of enormous significance, particularly for patients with osteoarthritis (OA). In this work, we applied Glycosaminoglycans-weighted Chemical Exchange Saturation Transfer (GagCEST) magnetic resonance imaging (MRI) at 7 Telsa (7T) to OA and healthy patients. GagCEST MRI revealed an increase in GagCEST (%) values for control patients in comparison to OA patients and can serve as a sensitive molecular biomarker for quantifying early metabolic changes in cartilage.

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