Texture analysis is currently being explored as an tool for evaluation of collagen specific T2 mapping in magnetic resonance imaging in osteoarthritis (OA) research. We assessed the effect of GLCM calculation offset and number of parameters used for T2 mapping of OA lesion and healthy cartilage on GLCM features. Significant differences in autocorrelation, contrast and homogeneity between lesion and reference when using combination of different offsets (0° and 90°) and 2- and 3-parameter T2 mapping were found. Considering architecture of healthy and OA cartilage and resultant T2 distribution, autocorrelation, contrast and homogeneity might be reliable indicators of cartilage damage.
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