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Abstract #3006

Cerebellar changes in Spinocerebellar Ataxia Type 2 and 12 in comparison with healthy controls

Pankaj pankaj1, S Senthil Kumaran1, and Achal Kumar Srivastava2
1NMR, All India Institute of Medical Sciences, New Delhi, India, 2Neurology, All India Institute of Medical Sciences, New Delhi, India

Spinocerebellar Ataxia (SCA), also known as spinocerebellar degeneration, is a degenerative, progressive and genetic disorder that leads to severe disability. On structural morphometrics of isolated cerebellum, we observed significant white matter atrophy in the anterior lobe of the SCA type 2 and 12 patients. Cerebellum atrophy of gray matter in both bilateral anterior and posterior cerebellar lobes, Cerebellar Tonsil, Uvula, Inferior Semi-Lunar Lobule, Declive, Red Nucleus and Substania Nigra was observed in SCA2, with respect to healthy controls. SCA2 patients exhibited more atrophy in comparison to SCA12. Atrophy in the cerebellum suggest deficits in motor and cognition in SCA patients.

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