Abstract #3007

Cerebro-cerebellar impact on brain dynamics in a single-subject with cerebellar ataxia

Silvia Maria Marchese¹, Fulvia Palesi^2,3, Mariagrazia Bruzzone⁴, Anna Nigri⁴, Stefano D'Arrigo⁵, Chiara Pantaleoni⁵, Claudia AM Gandini Wheeler-Kingshott^2,3,6, Egidio D'Angelo^2,3, and Paolo Cavallari¹

¹Human Physiology Section of the DePT, Università degli Studi di Milano, Milano, Italy, ²Department of Brain and Behavioral Science, Università degli Studi di Pavia, Pavia, Italy, ³Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy, ⁴Neuroradiology Department, Fondazione IRCCS Istituto Neurologico "C. Besta", Milano, Italy, ⁵Developmental Neurology Department, Fondazione IRCCS Istituto Neurologico "C. Besta", Milano, Italy, ⁶Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, NMR Research Unit, Queen Square MS Centre, London, United Kingdom

The simulation of whole-brain dynamics in a single-subject affected by Joubert syndrome (non-progressive pediatric cerebellar ataxia), allowed us to investigate the impact of cerebro-cerebellar connectivity in a brain network with cerebellar dysfunction. The prediction power resulted strongly disturbed with the exclusion of the cerebro-cerebellar network from the generation of cerebral activity. These preliminary results suggest that compensatory mechanisms and plasticity must have taken place in the damaged cerebellum itself to support whole brain functional dynamics.

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