The simulation of whole-brain dynamics in a single-subject affected by Joubert syndrome (non-progressive pediatric cerebellar ataxia), allowed us to investigate the impact of cerebro-cerebellar connectivity in a brain network with cerebellar dysfunction. The prediction power resulted strongly disturbed with the exclusion of the cerebro-cerebellar network from the generation of cerebral activity. These preliminary results suggest that compensatory mechanisms and plasticity must have taken place in the damaged cerebellum itself to support whole brain functional dynamics.
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