There is an evolving history of structural images with SCA3 patients in different disease stages. The WM damage starts with the impairment of ICP and goes through SCP extends to the midbrain, then widespread to the whole brain. The alteration of GMV does not occur until the arise of ataxia symptom, then began to involve the medulla, cerebellum, and pons, and developed to involve basal ganglion, finally affect the cortical cortex. The impairment of WM tracts precedes the GM atrophy and, irrespective of the patients with or without clinical manifestation, the identified WM damage was significantly correlated with SARA.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords