Abstract #3010

Volumetric estimation of various brain parts in Gluten Ataxia patients: A quantitative MRI study

Uma Sharma¹, Vishwa Rawat¹, Prasenjit Das ², Achal Kumar Srivastava³, and Govind Makharia⁴

¹Nuclear Magnetic Resonance and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Pathology, All India Institute of Medical Sciences, New Delhi, India, ³Neurology, All India Institute of Medical Sciences, New Delhi, India, ⁴Gasteroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India

Present study investigated volumetric volume changes in the brain of patients suffering from Gluten Ataxia (GA) using MRI. GA patients were seen to have significantly low brain and cerebellar volumes along the lobules which form the part of vermis suggesting cell degeneration and role of vermis in GA. GA patients also had significantly high levels of CSF. No significant changes were observed in whole brain grey matter, cerebrum, caudate, hippocampus and amygdala. Our results suggest that cerebrum volume is not linked to GA but lobes of cerebellum, whole brain white matter and CSF is significantly associated with GA.

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