Abstract #3012

Spatial changes of neuromelanin and iron content in substantial nigra pars compacta in early-stage idiopathic Parkinson’s disease

Zenghui Cheng¹, Bin Xiao², Naying He³, Dinggang Shen⁴, Qian Wang⁵, Feng Shi⁴, Youmin Zhang³, Pei Huang³, Yan Li³, Sean K Sethi⁶, Kiarash Ghassaban⁷, Shengdi Chen³, Fuhua Yan³, and Ewart Mark Haacke⁷

¹Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Medical Imaging Technology, 、School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ³Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Shanghai United Imaging Intelligence Co., Ltd., Shanghai, China, ⁵Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, ⁶Magnetic Resonance Innovations, Inc, Bingham Farms, MI, United States, ⁷Wayne State University, Detroit, MI, United States

Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by progressive loss of neuromelanin-containing dopaminergic neurons and iron deposition mainly in the substantia nigra (SN). Previous studies mainly focused on global changes in both neuromelanin (NM) and iron content. In this study, we used a voxel-wise analysis to investigate the spatial changes of iron and NM content in PD and found that the ventral and medial part of the SN pars compacta had more iron deposition and less neuromelanin, especially, in early-stage PD.

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