Abstract #3016

Substantia Nigra Neuromelanin-sensitive Imaging Biomarker to Differentiate Between Atypical Parkinsonian Syndromes

Rahul Gaurav^1,2,3, Emina Arsovic^1,4, Lydia Chougar^1,4, Nadya Pyatigorskaya^1,2,3,4, Marie Vidailhet^2,3,5, and Stephane Lehericy^1,2,3,4

¹CENIR, ICM Paris, Paris, France, ²Paris Brain Institute (ICM), Sorbonne University, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France, ³ICM Team “Movement Investigations and Therapeutics” (MOV’IT), Paris, France, ⁴Department of Neuroradiology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, ⁵Department of Neurology, APHP, Pitié-Salpêtrière Hospital, Paris, France

Atypical Parkinsonian disorders are progressive neurodegenerative diseases characterized clinically by parkinsonism, associated with degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Histological studies suggested that dopaminergic cell neurodegeneration pattern may differ between atypical Parkinsonian disorders and with Parkinson’s disease.

In this study, we aimed to quantify and compare SNc volume and signal intensity using neuromelanin-sensitive T1-weighted MRI between progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, dementia with Lewy body and sporadic Parkinson’s disease.

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