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Abstract #3016

Substantia Nigra Neuromelanin-sensitive Imaging Biomarker to Differentiate Between Atypical Parkinsonian Syndromes

Rahul Gaurav1,2,3, Emina Arsovic1,4, Lydia Chougar1,4, Nadya Pyatigorskaya1,2,3,4, Marie Vidailhet2,3,5, and Stephane Lehericy1,2,3,4
1CENIR, ICM Paris, Paris, France, 2Paris Brain Institute (ICM), Sorbonne University, UPMC Univ Paris 06, Inserm U1127, CNRS UMR 7225, Paris, France, 3ICM Team “Movement Investigations and Therapeutics” (MOV’IT), Paris, France, 4Department of Neuroradiology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France, 5Department of Neurology, APHP, Pitié-Salpêtrière Hospital, Paris, France

Atypical Parkinsonian disorders are progressive neurodegenerative diseases characterized clinically by parkinsonism, associated with degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Histological studies suggested that dopaminergic cell neurodegeneration pattern may differ between atypical Parkinsonian disorders and with Parkinson’s disease.

In this study, we aimed to quantify and compare SNc volume and signal intensity using neuromelanin-sensitive T1-weighted MRI between progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, dementia with Lewy body and sporadic Parkinson’s disease.

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