Meeting Banner
Abstract #3017

Fibre-specific white matter reduction in patients with multiple system atrophy: comparison of parkinsonian and cerebellar subtypes

Po-Yuan Chen1, Chih-Chien Tsai1, Chin-Song Lu2, Yi-Hsin Weng2, Yi-Ming Wu3, and Jiun-Jie Wang1
1Chang Gung University, Taoyuan, Taiwan, 2Chang Gung Memorial Hospital, Taoyuan, Taoyuan, Taiwan, 3Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan

Precise differentiation between MSA subtype is critical in medical intervention and prognosis. The results of previous studies using DTI to differentiate subtypes of MSA is controversial. We use fixel based analysis to examine the tract-specific differences in white matter between individuals with MSA and healthy controls. The results demonstrate the white matter degeneration in specific fibre bundle, including middle cerebellar peduncle, pontine crossing tract and cerebellar white matter tracts in the early MSA-C patients; in contrast, this pattern was not observed in MSA-P patients. This suggests that FBA may be a sensitive marker for early differential diagnosis of MSA subtype.

This abstract and the presentation materials are available to members only; a login is required.

Join Here