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Abstract #3022

Substantia nigra magnetic resonance spectrum in differentiating tremor-dominant Parkinson’s disease from essential tremors

Rushi Chen1, Yan Bai1, Qin Feng1, Menghuan Zhang1, Xianchang Zhang2, and Meiyun Wang1
1Henan provincial people's hospital, Zhengzhou, China, 2MR Collaboration, Siemens Healthcare Ltd, Beijing, China, Beijing, China

Conventional magnetic resonance imaging has limitations in differentiating Parkinson’s disease (PD) from essential tremors (ET). Magnetic resonance spectroscopy (MRS) can non-invasively detect neurochemical alterations in biological tissues. In this study, we used MRS to obtain N-acetylaspartate (NAA)/creatine (Cr) and choline (Cho)/Cr ratios in the substantia nigra (SN) of patients with tremor-dominant PD and ET. The NAA/Cr ratio in the contralateral SN was significantly higher in patients with tremor-dominant PD than those with ET, whereas the Cho/Cr ratios showed no significant differences between groups. The findings suggest that MRS in the SN may be helpful in differentiating tremor-dominant PD from ET.

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