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Abstract #3021

Quantitative mapping of substantia nigra iron and neuromelanin in Parkinson’s Disease

Jiahao Li1,2, Kelly Gillen1, Ilhami Kovanlikaya1, Thanh Nguyen1, Alexey Dimov1, Kailyn Li1, Weiyuan Huang1, Xianfu Luo1, Carly Skudin1, Eileen Chang1, Alexander Shtilbans1,3, and Yi Wang1,2
1Weill Cornell Medicine, New York, NY, United States, 2Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, United States, 3Hospital for Special Surgery, New York, NY, United States

Parkinson’s disease (PD) is a neurodegenerative disorder characterized pathologically by loss of dopaminergic neurons and accumulation of iron in the substantia nigra. Our MR imaging study uses quantitative susceptibility mapping (QSM) and magnetization transfer contrast (MTC) to quantify iron and neuromelanin, respectively in healthy controls, patients with REM sleep behavior disorder (RBD), and PD. We demonstrate that patients with PD have an increase in iron but reduction in neuromelanin in the substantia nigra as compared to healthy controls. Loss of dopaminergic neurons can cause release of neuromelanin, thus furthering a neuroinflammatory and neurodegenerative cycle1.

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