This study investigated the subcortical structural modifications associated with motor symptoms of Parkinson Disease (PD) over time.
Fifty subjects with PD performed two MRI sessions (baseline/48months). Motor symptoms were assessed using the Unified Parkinson’s Disease Rating Scale III.
Our results showed an atrophy over time in all subcortical regions linked to the progression of PD. Furthermore, a reduced volume in thalamus and an increased volume in pallidum were associated with a decline in motor skills, consistent with the model of thalamo-cortical functional loops. Finally, we confirm that VBM and volumetry are complementary tools to assess brain degeneration in PD.