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Abstract #3025

Subcortical grey matter changes associated with motor skills in Parkinson Disease: a longitudinal study

CĂ©line Charroud1 and Luca Turella1
1Center for Mind/Brain Sciences - CIMeC, Mattarello, Italy

This study investigated the subcortical structural modifications associated with motor symptoms of Parkinson Disease (PD) over time.

Fifty subjects with PD performed two MRI sessions (baseline/48months). Motor symptoms were assessed using the Unified Parkinson’s Disease Rating Scale III.

Our results showed an atrophy over time in all subcortical regions linked to the progression of PD. Furthermore, a reduced volume in thalamus and an increased volume in pallidum were associated with a decline in motor skills, consistent with the model of thalamo-cortical functional loops. Finally, we confirm that VBM and volumetry are complementary tools to assess brain degeneration in PD.

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