Abstract #3026

The perfusion deficits in general cognitive, executive, and visual dysfunction in Parkinson's disease measured by arterial spin labeling MRI

Dilek Betul Arslan¹, Hakan Ibrahim Gurvit², Ozan Genc¹, Sevim Cengiz¹, Ani Kicik^3,4, Kardelen Eryurek^4,5, Emel Erdogdu^4,6, Zerrin Yildirim², Zeynep Tufekcioglu², Aziz Mufit Ulug^1,7, Basar Bilgic², Hasmet Hanagasi², Tamer Demiralp^4,8, and Esin Ozturk-Isik¹

¹Biomedical Engineering, Biomedical Engineering Institution, Bogazici University, Istanbul, Turkey, ²Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ³Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, ⁴Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ⁵Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, ⁶Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, ⁷CorTechs Labs, San Diego, CA, United States, ⁸Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

The main aim of this study was to detect perfusion deficits at general executive, cognitive and visual domains of Parkinson's disease (PD) patients with mild cognitive impairment and normal cognition compared to healthy controls based on cerebral blood flow (CBF) maps obtained with arterial spin labeling MRI (ASL-MRI). CBF maps were calculated by fitting a general kinetic curve model for each pixel of ASL-MR images. A hypoperfusion pattern was observed in PD in line with general cognitive and executive dysfunction.

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