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Abstract #3026

The perfusion deficits in general cognitive, executive, and visual dysfunction in Parkinson's disease measured by arterial spin labeling MRI

Dilek Betul Arslan1, Hakan Ibrahim Gurvit2, Ozan Genc1, Sevim Cengiz1, Ani Kicik3,4, Kardelen Eryurek4,5, Emel Erdogdu4,6, Zerrin Yildirim2, Zeynep Tufekcioglu2, Aziz Mufit Ulug1,7, Basar Bilgic2, Hasmet Hanagasi2, Tamer Demiralp4,8, and Esin Ozturk-Isik1
1Biomedical Engineering, Biomedical Engineering Institution, Bogazici University, Istanbul, Turkey, 2Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 3Department of Physiology, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkey, 4Neuroimaging Unit, Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, 5Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, 6Department of Psychology, Faculty of Arts and Sciences, Isik University, Istanbul, Turkey, 7CorTechs Labs, San Diego, CA, United States, 8Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

The main aim of this study was to detect perfusion deficits at general executive, cognitive and visual domains of Parkinson's disease (PD) patients with mild cognitive impairment and normal cognition compared to healthy controls based on cerebral blood flow (CBF) maps obtained with arterial spin labeling MRI (ASL-MRI). CBF maps were calculated by fitting a general kinetic curve model for each pixel of ASL-MR images. A hypoperfusion pattern was observed in PD in line with general cognitive and executive dysfunction.

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