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Abstract #3027

Disrupted Functional Connectivity of the Nucleus basalis of Meynert in Parkinson's Disease patients with Mild Cognitive Impairment

Chao Zhang1, Weiqiang Dou2, and Kai Xu1
1Department of Radiology, Xuzhou Medical University, Xuzhou, China, 2GE Healthcare,MR Research China, Beijing, China

Different functional connectivities of Basal nucleus of Meynert (BNM-FC) and the other brain regions among patients with Parkinson’s Disease (PD) accompanied and not accompanied with mild cognition impairment (PD-MCIs and PD-NCs, respectively) have been investigated in this study. A model based on Support-Vector-Machine with BNM-FC and neuropsychological results showed significantly decreased BNM-FC in the right superior parietal lobe of PD-MCIs than PD-NCs, allowing an accurate differentiation between PD-MCIs and PD-NCls. These results advanced our knowledge of the cholinergic system underpinning cognitive function in PD individuals.

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