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Abstract #3028

Automated Magnetic Resonance Parkinsonism Index: Test-Retest Reliability and 10 Year Changes in Aging and Parkinson’s Disease

Yao-Chia Shih1,2, Bénédicte Maréchal3,4,5, Ricardo Corredor Jerez3,4,5, Septian Hartono2,6, Hui-Hua Li2,7, Isabel Hui Min Chew1, Eng King Tan2,6, and Ling Ling Chan1,2
1Department of Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore, 2Duke-NUS Medical School, Singapore, Singapore, 3Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 4Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 5LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6Department of Neurology, National Neuroscience Institute (Outram-campus), Singapore, Singapore, 7Health Services Research Unit, Singapore General Hospital, Singapore, Singapore

Progressive supranuclear palsy phenotypes are increasingly recognized and the Magnetic Resonance Parkinsonism Index (MRPI) useful in supporting clinical diagnosis. We examined the test-retest reliability of a landmark-based automated algorithm to derive MRPI from >2000 brain scans across different cohorts with neurodegeneration and MRI systems. We also investigated temporal changes in the MRPI derived from longitudinal scans 6–10 years apart in 53 subjects from case-control Parkinson’s disease cohorts. We found the automated MRPI fast (averaging 25s ± 2s per case) and reliable (average coefficient of variance <20%), without significant change in MRPI over time in aging and Parkinson’s disease.

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