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Abstract #3029

Magnetic resonance characteristics of iron and neuromelanin in early Parkinson’s disease: correlation with vesicular monoamine transporter 2

xueling Liu1, Pu-Yeh Wu2, and Yuxin Li1
1Department of Radiology, Huashan hospital affiliated to Fudan University, Shanghai, China, 2GE Healthcare, Beijing, China, Shang Hai, China

In this study, we investigated alterations of iron and NM in EPD, and correlations between them and VMAT2 binding in nigrostriatal system. Our results suggested that changes of neuromelanin and susceptibility on QSM images could quantitatively reflect the pathology of EPD and could be used as imaging biomarkers for diagnosing of EPD. The SUR measured by 18F-DTBZ images could reflect the lateralization in EPD patients. NM volume could reflect the striatal dopaminergic function, and both CR value and SUR could reflect the severity of motor impairment in EPD, which are expected to be used for monitoring the progression of EPD.

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