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Abstract #3030

Value of magnetic resonance fingerprinting for differentiating tremor-dominant Parkinson’s disease from essential tremors

Yan Bai1,2, Rushi Chen1,2, Wei Wei1,2, Rui Zhang1,2, Zhun Huang2,3, Xianchang Zhang4, Mathias Nittka5, Gregor Koerzdoerfer5, and Meiyun Wang1,2
1Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Academy of Medical Sciences., Zhengzhou, China, 2Henan Key Laboratory for Medical Imaging of Neurological Diseases, Zhengzhou, Henan, China, ZhengZhou, China, 3Department of Radiology, Henan University People’s Hospital & Henan Provincial People’s Hospital, School of Basic Medicine., Zhengzhou, China, 4MR Collaboration, Siemens Healthcare Ltd., Beijing, China, BeiJing, China, 5MR Pre-development, Siemens Healthcare GmbH, Erlangen, Germany, Erlangen, Germany

Conventional magnetic resonance imaging cannot reliably differentiate Parkinson’s disease (PD) from essential tremors (ET). Magnetic resonance fingerprinting (MRF) can simultaneously acquire T1 and T2 relaxometry. This study utilized MRF to obtain T1 and T2 values in substantia nigra (SN) of patients with tremor-dominant PD and ET. The T1 values of SN were significantly higher in patients with tremor-dominant PD than those with ET, whereas the T2 values showed no significant differences between groups. The findings suggest that MRF T1 mapping of the SN can potentially differentiate tremor-dominant PD from ET

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