Abstract #3030

Value of magnetic resonance fingerprinting for differentiating tremor-dominant Parkinson’s disease from essential tremors

Yan Bai^1,2, Rushi Chen^1,2, Wei Wei^1,2, Rui Zhang^1,2, Zhun Huang^2,3, Xianchang Zhang⁴, Mathias Nittka⁵, Gregor Koerzdoerfer⁵, and Meiyun Wang^1,2

¹Department of Radiology, Zhengzhou University People’s Hospital & Henan Provincial People’s Hospital, Academy of Medical Sciences., Zhengzhou, China, ²Henan Key Laboratory for Medical Imaging of Neurological Diseases, Zhengzhou, Henan, China, ZhengZhou, China, ³Department of Radiology, Henan University People’s Hospital & Henan Provincial People’s Hospital, School of Basic Medicine., Zhengzhou, China, ⁴MR Collaboration, Siemens Healthcare Ltd., Beijing, China, BeiJing, China, ⁵MR Pre-development, Siemens Healthcare GmbH, Erlangen, Germany, Erlangen, Germany

Conventional magnetic resonance imaging cannot reliably differentiate Parkinson’s disease (PD) from essential tremors (ET). Magnetic resonance fingerprinting (MRF) can simultaneously acquire T1 and T2 relaxometry. This study utilized MRF to obtain T1 and T2 values in substantia nigra (SN) of patients with tremor-dominant PD and ET. The T1 values of SN were significantly higher in patients with tremor-dominant PD than those with ET, whereas the T2 values showed no significant differences between groups. The findings suggest that MRF T1 mapping of the SN can potentially differentiate tremor-dominant PD from ET

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