Type 2 diabetes melitus(T2DM) is associated with worse motor imbalance and cognitive decline in Parkinson’s disease.Abnormal cerebral iron deposition occur in extrapyramidal system in PD patients. However, whether the microscopic iron deposition will increase further in Parkinson’s patients with T2DM remains unknown. In this study, the iron deposition in extrapyramidal system measured QSM was compared between Parkinson's patients with T2DM (PDDM) and Parkinson's patients without T2DM (PDND).The increased magnetic sensitivity values (MSV) were found in most brain gray matter nucleus,especially for the left globus pallidus(GP) and bilateral substantia nigra(SN),in PDDM group rather than in PDND group.
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