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Abstract #3036

Exposure to Traffic-Related Particulate Matter Impact Motor Function and White Mater Integrity in Elder Rodent Model

Ting-Chieh Chen1, Yu-Chun Lo2, Yi-Chen Lin1, Ssu-Ju Li1, Ting-Chun Lin1, Ching-Wen Chang1, Yao-Wen Liang1, Hsiao-Chi Chuang3, and You-Yin Chen1,2
1Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, 2Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan, 3School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan

Exposure to air pollution was demonstrated to be correlated with the neurodegenerative disease showing the cognitive deficits, but the impacts on motor function has yet to be investigated. The motor behavioral test and diffusion magnetic resonance imaging (MRI) tractography analysis were applied to the traffic-related particulate matter (PM)-exposed models in this study. We found the decline in motor function and the destruction of the microstructure after exposed to traffic-related PM for 3 months, in which the structural alterations of motor control circuit were similar to the characteristic of the Parkinson's disease (PD).

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