Abstract #3036

Exposure to Traffic-Related Particulate Matter Impact Motor Function and White Mater Integrity in Elder Rodent Model

Ting-Chieh Chen¹, Yu-Chun Lo², Yi-Chen Lin¹, Ssu-Ju Li¹, Ting-Chun Lin¹, Ching-Wen Chang¹, Yao-Wen Liang¹, Hsiao-Chi Chuang³, and You-Yin Chen^1,2

¹Biomedical Engineering, National Yang-Ming University, Taipei, Taiwan, ²Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan, ³School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan

Exposure to air pollution was demonstrated to be correlated with the neurodegenerative disease showing the cognitive deficits, but the impacts on motor function has yet to be investigated. The motor behavioral test and diffusion magnetic resonance imaging (MRI) tractography analysis were applied to the traffic-related particulate matter (PM)-exposed models in this study. We found the decline in motor function and the destruction of the microstructure after exposed to traffic-related PM for 3 months, in which the structural alterations of motor control circuit were similar to the characteristic of the Parkinson's disease (PD).

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