Abstract #3039

Evidence on the association between executive functions and tractography-derived nodal properties in Parkinson's disease

Giacomo Tomezzoli^1,2, Lisa Novello², Francesca Saviola², Stefano Tambalo², Beatrice Federica Luciani², Enrica Pierotti², Céline Charroud ², Alessandro Gober², Francesca Giacomoni², Pamela Narduzzi², Claudia Meli², Marika Falla², Alessandra Dodich², Luca Turella², Costanza Papagno², and Jorge Jovicich²

¹DiPSCo, Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy, ²CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy

Executive functions (EFs) play a crucial role for intact cognitive functioning, and their decline in Parkinson’s Disease (PD) patients is associated with decreased quality of life. We investigated the relationship between tractography-derived nodal properties in 8 brain regions involved in cognitive sub-components of executive control and EFs performance. We found preliminary evidence that graph-theory-derived nodal properties reveal associations with executive scores. As part of an ongoing longitudinal project, this initial evidence suggests that nodal metrics might be useful for investigating relationships between structural-connectivity properties and cognitive profiles in Parkinson’s disease.

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