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Abstract #3040

Patient-specific hyperdirect pathway activation in DBS for Parkinson’s Disease

Alba Segura Amil1,2 and T. A. Khoa Nguyen1,2
1Department of Neurosurgery, Inselspital, University Hospital Bern, Bern, Switzerland, 2ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland

Deep brain stimulation in the subthalamic nucleus is an effective treatment in advanced Parkinson’s disease. The aim of the current study was to determine an activation threshold of the hyperdirect pathway that results in the control of motor symptoms while avoiding the appearance of side effects. Patient-specific whole brain tractograpy, DBS leads reconstruction, and generation of volumes of tissue activated were performed in 9 subjects. The effect threshold was at 20% of hyperdirect pathway activation, while the side effect threshold was at 2% of corticospinal tract activation.

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