Abstract #3041

Brain structure network mediating the association between iron deposition and progression of Parkinson Disease

Bingxue Cheng¹, Chenfei Ye², and Ting Ma^1,2,3

¹Department of Information and Electronics, Harbin Institute of Technology at Shenzhen, GuangDong Province, China, ²Peng Cheng laboratory, Guangdong Province, China, ³National Clinical Research Center for Geriatric Disorders, Beijing, China

Our study integrated a high angular resolution diffusion imaging (HARDI) and Quantitative susceptibility mapping (QSM) to clarify whether the disease-specific patterns of the associated between iron deposits and the progress of PD are affected by the structural network. In brain sturctural network of PD, we observed that the increased small-worldness and decreased rich-club coefficients significantly mediate the association between the mean QSM value in left putamen and H&Y scale by using the causal mediation analysis.

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