We investigated the functional neural organization of the motor cerebro-cerebellar system in Parkinson’s disease (PD) patients with tremor-dominant (TD) or postural instability and gait disorder (PIGD) variant. A seed-cerebellar region (lobule VI of cerebellum) was defined based on motor task-based functional MRI in healthy controls. Functional connectivity was found to be disrupted in both PD subgroups between cerebellum, thalamus and default-mode regions. We identified different localization of functional over‐connectivity, PD-PIGD within inferior frontal gyrus and insula, while PD-TD in orbitofrontal gyrus. This study might provide novel insight into the underlying pathophysiological mechanism in PD subtypes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords