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Abstract #3043

Motor Cerebro-Cerebellar Networks Breakdown Among Different Subtypes of Parkinson’s Disease

Silvia Basaia1, Federica Agosta1,2,3, Alessandro Francia1, Camilla Cividini1,3, Tanja Stojkovic4, Iva Stankovic4, Rosita Di Micco1, Luigi Albano1, Elisabetta Sarasso1, Noemi Piramide1,3, Vladana Markovic4, Elka Stefanova4, Vladimir S. Kostic4, and Massimo Filippi1,2,3,5,6
1Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy, 2Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 3Vita-Salute San Raffaele University, Milan, Italy, 4Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Italy, 5Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, 6Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy

We investigated the functional neural organization of the motor cerebro-cerebellar system in Parkinson’s disease (PD) patients with tremor-dominant (TD) or postural instability and gait disorder (PIGD) variant. A seed-cerebellar region (lobule VI of cerebellum) was defined based on motor task-based functional MRI in healthy controls. Functional connectivity was found to be disrupted in both PD subgroups between cerebellum, thalamus and default-mode regions. We identified different localization of functional over‐connectivity, PD-PIGD within inferior frontal gyrus and insula, while PD-TD in orbitofrontal gyrus. This study might provide novel insight into the underlying pathophysiological mechanism in PD subtypes.

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