Abstract #3044

Diffusion Tensor Imaging and Tractography in Deep Brain Stimulation Postoperative Patients with Parkinson's Disease

Yan Li¹, Yu Liu¹, Naying He¹, Chencheng Zhang², Yijie Lai², Hongyang Li², Qing Li³, Caixia Fu⁴, Fuhua Yan¹, and Ewart Mark Haacke^1,5

¹Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ²Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ³MR Collaborations, Siemens Healthcare Ltd., Shanghai, China, ⁴MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁵Department of Radiology, Wayne State University, Detroit, MI, United States

Preliminary evidence supports the safety of diffusion weighted tractography in postoperative patients with deep brain stimulation. Here we further test the feasibility in both DBS-on and DBS-off status. Both DBS ON and OFF diffusion weighted imaging are safe and the tractography results are significantly comparable. Furthermore, we found that the nigrostriatal pathway's deterministic tractography is feasible. Our results highlight that DBS ON DTI is particularly fitting for those patients who cannot control their disease symptoms without stimulation but need MRI.

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