Imperfect spoiling introduces a bias in T1 times estimated with the Variable Flip Angle approach. Correction factors accounting for B1+ inhomogeneities have been proposed but a T2 dependent bias is expected to remain. Here we assess the amplitude of this effect at 7T with a commonly used multi-echo protocol and multiple radiofrequency spoiling increments and gradient spoiler moments. The T2 dependence is observed in-vivo and varies across spoiling conditions. Given that correction schemes don’t account for T2 variability, we recommend to use the least sensitive increment, such as 117° or 144°, in association with sufficient spoiling gradient (6π per TR).