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Abstract #3045

Residual T2 dependent bias of T1 times estimated with the Variable Flip Angle approach at 7T: Evaluation and recommendations.

Nadège Corbin1,2 and Martina F. Callaghan1
1Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 2Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536, CNRS/University Bordeaux, Bordeaux, France

Imperfect spoiling introduces a bias in T1 times estimated with the Variable Flip Angle approach. Correction factors accounting for B1+ inhomogeneities have been proposed but a T2 dependent bias is expected to remain. Here we assess the amplitude of this effect at 7T with a commonly used multi-echo protocol and multiple radiofrequency spoiling increments and gradient spoiler moments. The T2 dependence is observed in-vivo and varies across spoiling conditions. Given that correction schemes don’t account for T2 variability, we recommend to use the least sensitive increment, such as 117° or 144°, in association with sufficient spoiling gradient (6π per TR).

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