A growing number of clinical applications rely on quantitative mapping of relaxation times and apparent diffusion coefficient (ADC). In addition, research interest in understanding the interplay between relaxation and diffusion processes is rising. Conventional methods for mapping relaxation and diffusion parameters require separate scans, resulting in not only a long acquisition time but also image co-registration challenges when inter-scan motion is present. We herein report a stimulated multi-echo-train EPI sequence with diffusion-weighting to achieve simultaneous, co-registered T1, T2* and ADC mapping. This technique was implemented at 3T and demonstrated in the brain and the prostate of healthy human subjects.
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