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Abstract #3065

Neuromelanin-Related Proton Relaxation of Water: Influence from Iron and Copper

Niklas Wallstein1, André Pampel 1, Andrea Capucciati2, Carsten Jäger1, Fabio A. Zucca3, Luigi Casella2, Luigi Zecca3, and Harald E. Möller1
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Department of Chemistry, University of Pavia, Pavia, Italy, 3Institute of Biomedical Technologies, National Research Council of Italy, Segrate, Milan, Italy

Neuromelanin (NM) MRI has received increasing interest in applications to diagnosis of Parkinson’s disease. A reduction of T1 associated with paramagnetic melanin-iron complexes is assumed to be the primary contrast mechanism. NM is able to chelate large quantities of iron but also, to a lesser extent, other transition metals, in particular copper. Here, we investigated the effect of different copper/iron concentrations bound to NM on water T1 and T2. Our results corroborate previous studies suggesting a concentration-dependent decrease of T1 for iron-loaded melanin. Additionally, we found a synergetic effect if both metals are simultaneously present leading to a pronounced T1-shortening.

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