Abstract #3069

Derivation of Water Exchange Constants between Components using Quantitative Parameter Mapping (QPM).

Naoki Maeda¹, Yuki Kanazawa², Masafumi Harada², Yo Taniguchi³, Yuki Matsumoto², Hiroaki Hayashi⁴, Kosuke Ito³, Yoshitaka Bito³, and Akihiro Haga²

¹Graduate of Health Science, Tokushima University, Tokushima, Japan, ²Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan, ³Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan, ⁴College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

We developed a method for deriving water exchange rate based on mcDESPOT approach between two structures using quantitative parameters calculated from QPM-MRI. Our method was performed with human study for ten healthy volunteers and one patient with brain tumor. There was a significant negative correlation between k_FS and k_SF derived from QPM in each region, e.g., white matter, gray matter, and cerebral spinal fluid of healthy volunteers. (R = -0.75, P < 0.001). In conclusion, water exchange rates derived from QPM make it possible to obtain more detailed information of the brain associated with proton diffusion between structures, i.e., cross-relaxation.

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