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Abstract #3069

Derivation of Water Exchange Constants between Components using Quantitative Parameter Mapping (QPM).

Naoki Maeda1, Yuki Kanazawa2, Masafumi Harada2, Yo Taniguchi3, Yuki Matsumoto2, Hiroaki Hayashi4, Kosuke Ito3, Yoshitaka Bito3, and Akihiro Haga2
1Graduate of Health Science, Tokushima University, Tokushima, Japan, 2Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan, 3Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan, 4College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

We developed a method for deriving water exchange rate based on mcDESPOT approach between two structures using quantitative parameters calculated from QPM-MRI. Our method was performed with human study for ten healthy volunteers and one patient with brain tumor. There was a significant negative correlation between kFS and kSF derived from QPM in each region, e.g., white matter, gray matter, and cerebral spinal fluid of healthy volunteers. (R = -0.75, P < 0.001). In conclusion, water exchange rates derived from QPM make it possible to obtain more detailed information of the brain associated with proton diffusion between structures, i.e., cross-relaxation.

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