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Abstract #3070

Radiomics with 3D MR fingerprinting: Influence of dictionary design on radiomic features and a potential mitigation strategy

Shohei Fujita1,2, Akifumi Hagiwara1, Koichiro Yasaka3, Hiroyuki Akai3, Akira Kunimatsu3, Shigeru Kiryu4, Issei Fukunaga1, Shimpei Kato1,2, Toshiaki Akashi1, Koji Kamagata1, Akihiko Wada1, Osamu Abe2, and Shigeki Aoki1
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Department of Radiology, The University of Tokyo, Tokyo, Japan, 3Department of Radiology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, 4Department of Radiological Sciences, International University of Health and Welfare, Narita, Japan

Understanding the dependencies of radiomic features on the dictionary step size in MR fingerprinting is crucial in the clinical implementation of MR fingerprinting-based radiomics. We investigated the influence of dictionary design in the radiomic analysis of MR fingerprinting and observed that radiomic features vary significantly for different designs. Moreover, special attention is required when using datasets containing maps generated from different dictionaries. We also demonstrated that an inverse quantization process can mitigate the influence of dictionary design on the radiomic features obtained with MR fingerprinting.

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