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Abstract #3122

Compact MRI bioreactor for real-time monitoring 3D printed tissue-engineered constructs.

Jean-Lynce GNANAGO1,2,3,4,5,6, Tony GERGES1,2,3,4,5,6, Laura Chastagnier1,2,4,6,7,8,9,10, Emma Petiot2,4,6,7,8,9,10, Vincent SEMET1,2,4,5,6, Philippe Lombard1,2,3,4,5,6, Christophe Marquette1,2,4,6,7,8,9,10, Michel Cabrera1,2,3,4,5,6, and Simon Auguste Lambert1,2,3,4,5,6
1Université Claude Bernard Lyon 1, VILLEURBANNE, France, 2INSA LYON, VILLEURBANNE, France, 3Ecole Centrale Lyon, Ecully, France, 4CNRS, VILLEURBANNE, France, 5AMPERE UMR 5005, VILLEURBANNE, France, 6Université de Lyon, VILLEURBANNE, France, 73d.FAB, VILLEURBANNE, France, 8CPE Lyon, VILLEURBANNE, France, 9ICBMS, VILLEURBANNE, France, 10UMR 5246, VILLEURBANNE, France

Tissue engineering for regenerative medecine is a growing field which faces structural and functional challenges at different scales. Real-time quantitative 3D characterization of tissues both in vitro and in vivo would help biologists assessing their methods. Magnetic Resonance Imaging (MRI) offers the possibility to perform such characterization non-invasively. We propose here a 7T MRI coil integrated within a perfusion tissue engineering bioreactor to perform tissue assessments throughout its growth. The MRI bioreactor is built using 3D printing and plastronics. This works resulted in a successful observation of a bioprinted tissue with a 75 µm in plane resolution.

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